4,238 research outputs found

    Green's functions on finite lattices and their connection to the infinite lattice limit

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    It is shown that the Green's function on a finite lattice in arbitrary space dimension can be obtained from that of an infinite lattice by means of translation operator. Explicit examples are given for one- and two-dimensional lattices

    Identification of Hazard and Risk for Glacial Lakes in the Nepal Himalaya Using Satellite Imagery from 2000–2015

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    Glacial lakes in the Nepal Himalaya can threaten downstream communities and have large socio-economic consequences if an outburst flood occurs. This study identified 131 glacial lakes in Nepal in 2015 that are greater than 0.1 km ²and performed a first-pass hazard and risk assessment for each lake. The hazard assessment included mass entering the lake, the moraine stability, and how lake expansion will alter the lake’s hazard in the next 15–30 years. A geometric flood model was used to quantify potential hydropower systems, buildings, agricultural land, and bridges that could be affected by a glacial lake outburst flood. The hazard and downstream impacts were combined to classify the risk associated with each lake. 11 lakes were classified as very high risk and 31 as high risk. The potential flood volume was also estimated and used to prioritize the glacial lakes that are the highest risk, which included Phoksundo Tal, Tsho Rolpa, Chamlang North Tsho, Chamlang South Tsho, and Lumding Tsho. These results are intended to assist stakeholders and decision makers in making well-informed decisions with respect to the glacial lakes that should be the focus of future field studies, modeling efforts, and risk-mitigation actions

    Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss

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    The association between hypoalbuminemia and poor prognosis in patients with cancer is well recognized. However, the factors that contribute to the fall in albumin concentrations are not well understood. In the present study, we examined the relationship between circulating albumin concentrations, weight loss, the body cell mass (measured using total body potassium), and the presence of an inflammatory response (measured using C- reactive protein) in male patients (n=40) with advanced lung or gastrointestinal cancer. Albumin concentrations were significantly correlated with the percent ideal body weight (r=0.390, p lt 0.05), extent of reported weight loss (r=-0.492, p lt 0.01), percent predicted total body potassium (adjusted for age, height, and weight, r=0.686, p lt 0.001), and logo C-reactive protein concentrations (r=-0.545, p lt 0.001). On multiple regression analysis, the percent predicted total body potassium and log(10) C-reactive protein concentrations accounted for 63% of the variation in albumin concentrations (r(2) = 0.626, p lt 0.001). The interrelationship between albumin, body cell mass, and the inflammatory response is consistent with the concept that the presence of an ongoing inflammatory response contributes to the progressive loss of these vital protein components of the body and the subsequent death of patients with advanced cancer

    Inherited polyglutamine spinocerebellar ataxias in South Africa

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    Objective. To determine the frequency and distribution ofpolyglutamine spinocerebellar ataxias (SCAs) from referrals over a24-year period to the National Health Laboratory Service (NHLS)in South Africa (SA).Methods. Paper-based clinical reports in the University ofCape Town laboratory and the NHLS electronic patient recorddatabase spanning a 24-year period were mined for informationregarding the molecular diagnosis, ethnicity and CAG repeatlength for individuals referred for molecular genetic testing for thepolyglutamine SCAs.Results. SCA1 and 7 are the most frequent types of polyglutamineSCA in the SA patient population, followed by SCA2, 3 and 6.SCA1 is the most common type in the coloured, white and Indianpopulations, whereas the majority of indigenous black Africanpatients are affected with SCA7 and 2. Of individuals tested, 22%were found to be positive for one of the polyglutamine SCAs.Conclusion. Although trends in the frequency and distributionof the polyglutamine SCAs in SA have not changed significantlysince our previous study in 2003, they differ remarkably from thosereported elsewhere, and reflect the unique genetic and demographicbackground of SA. The provision of accurate and complete patientinformation and family history is crucial to the diagnostic process,to enable comprehensive epidemiological studies and assist indeveloping therapeutic and patient management strategies
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